PharmaJet Partner Zydus Cadila Seeks EUA on World’s First Plasmid DNA COVID-19 Vaccine | Business Wire

The ZyCoV-D vaccine is the first ever plasmid DNA vaccine for human use and represents a key milestone in scientific innovation and technology advancement. It is delivered intradermally using the PharmaJet Tropis Needle-free Injection System, which enables enhanced vaccine effectiveness in addition to being highly preferred by patients and providers over other delivery methods1. The DNA platform is ideally suited for a COVID-19 vaccine as it can be easily adapted to deal with mutations in the virus and has greater thermostability and less restrictive cold chain requirements compared with other vaccines.

ZyCoV-D administered with the PharmaJet® Tropis® Needle-free device has already established a robust immunogenicity and tolerability and safety profile with its 66.6% efficacy for RT-PCR positive cases in the interim analysis. No moderate cases of COVID-19 were observed in the vaccine arm post administration of its third dose, clocking a 100% efficacy for moderate disease. In addition to adults, the vaccine is safe for adolescents 12 to 18 years of age.

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