https://www.frontiersin.org/articles/10.3389/fviro.2022.834808/full
A team of international researchers, including from India, have found that the COVID-19 virus’ contains a tiny chunk of DNA that matched the sequence patented by Moderna three years before the onset of the pandemic.
The findings, published in Frontiers in Virology, has raised new suspicion that the COVID-19 virus may have been tinkered within a lab, Daily Mail reported.
The scientists’ team, including Akhil Varshney from Dr Shroff Charity Eye Hospital in New Delhi, showed a tiny snippet of a genetic material owned by Moderna in the virus’s spike protein.
But records show that Moderna had filed the patent in February 2016 as part of its cancer research division, the report said.
Among numerous point mutation differences between the SARS-CoV-2 and the bat RaTG13 coronavirus, only the 12-nucleotide furin cleavage site (FCS) exceeds 3 nucleotides. A BLAST search revealed that a 19 nucleotide portion of the SARS.Cov2 genome encompassing the furing cleavage site is a 100% complementary match to a codon-optimized proprietary sequence that is the reverse complement of the human mutS homolog (MSH3).
The reverse complement sequence present in SARS-CoV-2 may occur randomly but other possibilities must be considered. Recombination in an intermediate host is an unlikely explanation. Single stranded RNA viruses such as SARS-CoV-2 utilize negative strand RNA templates in infected cells, which might lead through copy choice recombination with a negative sense SARS-CoV-2 RNA to the integration of the MSH3 negative strand, including the FCS, into the viral genome. In any case, the presence of the 19-nucleotide long RNA sequence including the FCS with 100% identity to the reverse complement of the MSH3 mRNA is highly unusual and requires further investigations.
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