Northwestern University gene-editing experiment turns hamsters violent

https://nypost.com/2022/05/29/northwestern-university-gene-editing-experiment-turns-hamsters-violent/#amp_tf=From%20%251%24s&aoh=16538670837070&csi=1&referrer=https%3A%2F%2Fwww.google.com&ampshare=https%3A%2F%2Fnypost.com%2F2022%2F05%2F29%2Fnorthwestern-university-gene-editing-experiment-turns-hamsters-violent%2F

A gene-editing experiment conducted on hamsters turned the adorable, furry pets into “aggressive” little monsters, researchers said.

Scientists at Northwestern University used controversial CRISPR technology to remove hormone vasopressin and its receptor, Avpr1a, from a group of the critters with the expectation that increase cooperation between the critters, according to the study.

The hypothesis was wrong.

“We were really surprised at the results,” H. Elliot Albers, one of the lead researchers in the study, told Metro.

“We anticipated that if we eliminated vasopressin activity, we would reduce both aggression and social communication.”

Once gene-spliced, the hamsters exhibited “high levels of aggression towards other same-sex individuals,” the professor said, regardless of sexuality or genotype.

Behaviors included chasing, biting and pinning, the study found.

Researchers said they chose to work with Syrian hamsters there social structure is similar to that of humans.

“We don’t understand this system as well as we thought we did,” Albers concluded.

https://assets.modernatx.com/m/197fe68e2047ca6a/original/US10703789.pdf
https://assets.modernatx.com/m/197fe68e2047ca6a/original/US10703789.pdf

https://assets.modernatx.com/m/6fa93a4f95208572/original/US10702600.pdf
Reversal of Diabetes Insipidus in Brattleboro Rats: Intrahypothalamic Injection of Vasopressin mRNA
Abstract
Messenger RNAs occur within the axons of magnocellular hypothalamic neurons known to secrete oxytocin and vasopressin. In Brattleboro rats, which have a genetic mutation that renders them incapable of vasopressin expression and secretion and thus causes diabetes insipidus, injection into the hypothalamus of purified mRNAs from normal rat hypothalami or of synthetic copies of the vasopressin mRNA leads to selective uptake, retrograde transport, and expression of vasopressin exclusively in the magnocellular neurons. Temporary reversal of their diabetes insipidus (for up to 5 days) can be observed within hours of the injection. Intra-axonal mRNAs may represent an additional category of chemical signals for neurons.

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