Serious Adverse Events of Special Interest Following mRNA Vaccination in Randomized Trials by Joseph Fraiman, Juan Erviti, Mark Jones, Sander Greenland, Patrick Whelan, Robert M. Kaplan, Peter Doshi :: SSRN

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4125239

https://www.israel365news.com/270568/covid-vaccine-impairs-ability-of-sperm-to-swim-israeli-study-reveals/

https://www.israel365news.com/270568/covid-vaccine-impairs-ability-of-sperm-to-swim-israeli-study-reveals/

ABSTRACT
Introduction. In 2020, prior to COVID-19 vaccine rollout, the Coalition for Epidemic
Preparedness Innovations and Brighton Collaboration created a priority list, endorsed by the World Health Organization, of potential adverse events relevant to COVID-19 vaccines. We
leveraged the Brighton Collaboration list to evaluate serious adverse events of special interest observed in phase III randomized trials of mRNA COVID-19 vaccines.

Methods. Secondary analysis of serious adverse events reported in the placebo-controlled,
phase III randomized clinical trials of Pfizer and Moderna mRNA COVID-19 vaccines
(NCT04368728 and NCT04470427), focusing analysis on potential adverse events of special
interest identified by the Brighton Collaboration.

Results. Pfizer and Moderna mRNA COVID-19 vaccines were associated with an increased
40 risk of serious adverse events of special interest, with an absolute risk increase of 10.1 and 15.1 per 10,000 vaccinated over placebo baselines of 17.6 and 42.2 (95% CI -0.4 to 20.6 and -3.6 to 33.8), respectively. Combined, the mRNA vaccines were associated with an absolute risk
increase of serious adverse events of special interest of 12.5 per 10,000 (95% CI 2.1 to 22.9).
The excess risk of serious adverse events of special interest surpassed the risk reduction for
COVID-19 hospitalization relative to the placebo group in both Pfizer and Moderna trials (2.3 and 6.4 per 10,000 participants, respectively).

Discussion. The excess risk of serious adverse events found in our study points to the need for
formal harm-benefit analyses, particularly those that are stratified according to risk of serious
COVID-19 outcomes such as hospitalization or death.


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