Lab-grown blood transfused to people in world-first clinical trial

Leviticus 17:11
King James Version
11 For the life of the flesh is in the blood: and I have given it to you upon the altar to make an atonement for your souls: for it is the blood that maketh an atonement for the soul.

LONDON — Blood grown in a laboratory has been transfused into humans for the first time in a landmark clinical trial that U.K. researchers say could significantly improve treatment for people with blood disorders and rare blood types.

Two patients in the U.K. received tiny doses — equivalent to a few teaspoons — of the lab-grown blood in the first stage of a wider trial designed to see how it behaves inside the body.

How does the technology work?

The research, which was conducted by researchers in Bristol, Cambridge and London, as well as NHS Blood and Transplant, focuses on red blood cells that carry oxygen from the lungs to the rest of the body.

Those stems were then placed in a nutrient solution in a laboratory. Over the course of around three weeks, the solution encouraged those cells to multiply and develop into more mature cells.

The cells were then purified using a standard filter — the same kind of filter that is used when regular blood donations are processed to remove white blood cells — before being stored and later transfused into the patients.

For the trial, the lab-grown blood was tagged with a radioactive substance, often used in medical procedures, to monitor how long it lasts in the body.

The same process will now be applied for a trial of 10 volunteers, who will each receive two donations of 5-10mls at least four months apart — one of normal blood and one of lab-grown blood — to compare the cells’ lifespans.

Patent – Method for producing red blood cells

The invention relates to a method for the expansion and differentiation of haematopoietic stem cells into enucleated erythrocytes, in two steps: a first step in a culture medium, where cell proliferation and erythmid differentiation are induced in the presence of growth factors, and a second step modeling a reconstitution of the microenvironment, substantially without erythropoietin (EPO). Optionally, the method of culture may comprise an intermediate step, with haematopoietic growth factors.

Construction of recombinant DNA, in which a foreign DNA fragment is inserted into a plasmid vector. In this example, the gene indicated by the white color is inactivated upon insertion of the foreign DNA fragment.

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