COVID-19 vaccination protects people with B cell lymphoma and multiple myeloma | News-Medical (Abomination Shot Adverse Events)

People with hematologic malignancies are at greater risk of severe coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, studies exploring the immune response to the COVID-19 vaccine have been scarce. A recent Nature Cancer study documented that individuals with B cell lymphomas (LY) and multiple myeloma (MM) developed potent infection neutralization capabilities against several SARS-CoV-2 variants of concern (VoCs).

About the Study
Patients with cancer have shown high mortality and morbidity rates due to SARS-CoV-2 infection. Such individuals often have secondary immunodeficiency and contract severe disease. Studies have demonstrated the efficacy of available vaccines in reducing disease severity in immunocompetent individuals, inducing both T-cell and humoral responses.

The current study deployed a longitudinal approach to study the T cell and humoral immune responses generated by two and three vaccine doses, using mainly the BNT162b2 mRNA vaccine. The cohort of individuals had different B cell LYs and MM. Researchers were able to obtain a thorough picture of vaccine-induced immune responses in this group compared to a healthy control group. Parallel and time-resolved assessment of antibody titers to viral spike protein, neutralization capacity, and antibody avidity to six authentic, replication-competent viruses, and HCoV OC43- and SARS-CoV-2-directed T cell responses were analyzed.

Key Findings
Six key findings were reported in the current study. First, compared to healthy individuals, individuals with hematologic malignancy demonstrated only a slightly lower infection neutralization capacity against SARS-CoV-2 variants. This was despite much lower antibody titers to the spike protein in the treated group.

Second, the per anti-spike antibody unit neutralizing potency was drastically enhanced in individuals with hematologic malignancies (20.8 fold on average), compared to the control group. This enhancement was observed early after the second vaccination. Third, compared to healthy individuals, the treated group showed higher avidity of serum IgG binding to the viral spike protein ahead of receiving the third vaccine dose.

Fourth, the Omicron (BA.1) and, to a lesser extent, Beta and Delta VoCs showed the greatest humoral immune escape. This finding was consistent with recent results on healthy individuals post-vaccination or infection. Fifth, the dominant share of study participants mounted robust vaccine-induced T-cell responses to several recent VoCs. This group included those participants that had LY and were receiving Rx treatment. Sixth, no COVID-19-related death was reported in the study cohort and the clinical presentation during breakthrough infections proved that the vaccine offered partial protection in immunocompromised individuals with hematologic malignancies.

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