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New research has provided answers to a mystery involving an outbreak of severe hepatitis in children last year.
Children in about 35 countries, including the United States, experienced severe hepatitis that caused 50 kids to need liver transplants and 22 children to die, according to the study led by researchers at the University of California, San Francisco (UCSF).
The researchers linked the disease to co-infections from multiple common viruses, in particular a strain of adeno-associated virus type 2 (AAV2).
While these AAVs are not known to cause hepatitis on their own, they can with “helper” viruses, such as adenoviruses that cause colds and flu, the study authors explained.
Children who had returned to school were more susceptible to these severe infections.
For a small subset of these children, getting more than one infection at the same time may have made them more vulnerable to severe hepatitis, the investigators found.
“We were surprised by the fact that the infections we detected in these children were caused not by an unusual, emerging virus, but by common childhood viral pathogens,” said senior study author Dr. Charles Chiu , director of the UCSF Clinical Microbiology Laboratory.
“That’s what led us to speculate that the timing of the outbreak was probably related to the really unusual situations we were going through with COVID 19-related school and daycare closures and social restrictions,” Chiu said in a university news release. “It may have been an unintended consequence of what we have experienced during the last two to three years of the pandemic.”
By August 2022, there were 358 cases being investigated in the United States and clusters of cases in 34 other countries.
Moderna Patent– https://assets.modernatx.com/m/6dc651c06fafd781/original/US10064959.pdf
Pfizer Adverse Events Doc – hepatitis (6 Findings)
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