A deadly bacteria with a roughly 50 percent fatality rate worldwide has made its way to the US Gulf Coast, where it has been declared endemic by the Centers for Disease Control and Prevention.
According to the NYP, The CDC has confirmed three cases of infection from the bacteria Burkholderia pseudomallei, which can cause potentially lethal melioidosis if not treated.
“It is an environmental organism that lives naturally in the soil, and typically freshwater in certain areas around the world. Mostly in subtropical and tropical climates,” Julia Petras, an epidemic intelligence service officer with CDC’s National Center for Emerging and Zoonotic Infectious Diseases, told HealthDay News.
The most recent case was reported in Mississippi in January. Two others were confirmed in the same Mississippi county in July 2020 and May 2020. However, most of those people infected with the bacteria don’t show symptoms and develop antibodies against it, meaning many more people are likely infected, Petras said.
In all three Mississippi cases, the patient recovered. “This is one of those diseases that is also called the great mimicker because it can look like a lot of different things,” Petras told the outlet.
“It’s greatly under-reported and under-diagnosed and under-recognized — we often like to say that it’s been the neglected, neglected tropical disease.” People are typically infected by the bacteria through open wounds or by inhaling the germs during a strong storm.
Those with diabetes or kidney and liver problems are most at risk. “Excessive alcohol use is also a known risk factor, and binge drinking has actually been associated with cases as well from endemic areas,” Petras said.
The CDC defines an endemic as “a constant amount of that specific disease present in a geographic location, like a state or country.” There have only ever been two reported cases in the world of bacteria spreading from person to person.
Once the bacteria is inside the body, it attacks organs like the lungs and brain and any organ with an abscess, Petras said. “A lot of patients will have pneumonia with sepsis, and or sepsis, which is associated with higher mortality and worse outcomes,” she said.
Globally, about 160,000 cases are reported annually, with 80,000 deaths. Petras said it’s important to diagnose melioidosis early so it can be properly treated.
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Why is this bacteria significant?
Historical cases and potential use in war
Glanders has been known since antiquity, with a description by Hippocrates around 425 BCE.
From the Middle Ages to the 1900s, glanders was a significant threat to armies.Before the Battle of Blenheim in 1704, glanders may have afflicted and greatly diminished the horses of Marshal Tallard’s cavalry, helping the Duke of Marlborough win the battle.
Glanders was a significant problem for civilian use of horses, as well. In the 18th-century veterinary hospital at the École Nationale Vétérinaire d’Alfort, glanders was the most common disease among their equine patients and the one most likely to cause death.
Due to the high mortality rate in humans and the small number of organisms required to establish infection, B. mallei is regarded as a potential biological warfare or bioterrorism agent, as is the closely related organism, B. pseudomallei, the causative agent of melioidosis.
During World War I, glanders was believed to have been spread deliberately by German agents to infect large numbers of Russian horses and mules on the Eastern Front. Other agents attempted to introduce the disease in the United States and Argentina. This had an effect on troop and supply convoys, as well as on artillery movement, which were dependent on horses and mules. Human cases in Russia increased with the infections during and after WWI.
The Japanese deliberately infected horses, civilians, and prisoners of war with B. mallei at the Unit 731 Pingfang (China) Institute and Unit 100 facilities during World War II. The U.S. studied this agent as a possible biological weapon in 1943–44, but did not weaponize it. U.S. interest in glanders (agent LA) continued through the 1950s, except it had an inexplicable tendency to lose virulence in the lab, making it difficult to weaponize. Between 1982 and 1984, the Soviet Union allegedly used weaponized B. mallei during the Soviet–Afghan War.
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